Clostar-GM Cream 16 gm is a combination of three drugs, namely: Clobetasol, Clotrimazole, and Neomycin used to treat fungal and bacterial infections of the skin. Clobetasol belongs to the class of corticosteroids that works by acting inside skin cells and inhibits the release of certain chemical messengers in the body that cause redness, itching, and swelling. When the skin reacts to any allergens, such chemicals are released normally. The fungal cell membranes are essential for their survival as they prevent the entry of unwanted substances into the cells and stop the leakage of cell contents. Clotrimazole is an antifungal that works by causing holes in the fungal cell membranes and kills fungi. Neomycin is a broad-spectrum antibiotic that acts against both gram-positive and gram-negative bacteria. It works by inhibiting the production of essential proteins that are necessary for bacteria to grow, multiply and increase in numbers. Thereby, destroys bacteria.